Research on Intravenous Infusions
This page offers a delineation of scientific research articles on the use of intravenous infusion therapy, intended for educational purposes only. Research should always be evaluated critically by the reader, and medical and healthcare decisions should always be made by consulting with a suitably qualified healthcare practitioner.
Intravenous Infusions
On Safe and Legal Use in South Africa
The South African Society of Psychiatrists (SASOP) and the South African Society of Anaesthesiologists (SASA) Joint Position Statement on the use of [medical] agents.
​
2022 on combining ACT therapy with infusions.
Mathai, D. S., Mora, V., & Garcia-Romeu, A. (2022). Toward Synergies of [Infusions] and Psychotherapy. Frontiers in Psychology, 1203.
2022 systematic narrative review of intravenous infusion therapy.
Drozdz, S. J., Goel, A., McGarr, M. W., Katz, J., Ritvo, P., Mattina, G. F., … & Ladha, K. S. (2022). [Infusion] Assisted Psychotherapy: A Systematic Narrative Review of the Literature. Journal of Pain Research, 15, 1691.
2022 therapy augments effects of infusion for alcohol use disorder.
Grabski, M., McAndrew, A., Lawn, W., Marsh, B., Raymen, L., Stevens, T., … & Morgan, C. J. A. (2022). Adjunctive [Infusions] With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder. The American Journal of Psychiatry, appiajp202121030277-appiajp202121030277.
2022 optimizing intravenous infusion treatment with trauma-informed psychotherapy.
Muscat, S. A., Hartelius, G., Crouch, C. R., & Morin, K. W. (2022). Optimized Clinical Strategies for Treatment-Resistant Depression: Integrating [Infusion] Protocols with Trauma-and Attachment-Informed Psychotherapy. Psych, 4(1), 119-141.
2021 therapy enhances durability of treatment effect.
Wilkinson, Samuel T., et al. “Cognitive behavioral therapy to sustain the antidepressant effects of [infusions] in treatment-resistant depression: a randomized clinical trial.” Psychotherapy and psychosomatics 90.5 (2021): 318-327.
2019 mindfulness-based therapy enhances positive effects with cocaine dependence.
Dakwar, Elias, et al. “A single infusion combined with mindfulness-based behavioral modification to treat cocaine dependence: a randomized clinical trial.” American Journal of Psychiatry.
Infusions & Depression
2021 narrative review of [Infusions] for depression.
Jelen, Luke A., and James M. Stone. “[Infusions] for depression.” International Review of Psychiatry 33.3 (2021): 207-228.
2021 international expert opinion.
McIntyre, Roger S., et al. “Synthesizing the evidence for [infusions] in treatment-resistant depression: an international expert opinion on the available evidence and implementation.” American Journal of Psychiatry 178.5 (2021): 383-399.
2021 systematic review of 83 trials.
Walsh, Zach, et al. “[Infusions] for the treatment of mental health and substance use disorders: comprehensive systematic review.” BJPsych Open 8.1 (2022).
2021 systematic review and meta-analysis.
Bahji, Anees, Gustavo H. Vazquez, and Carlos A. Zarate Jr. “Comparative efficacy of racemic [Infusions] for depression: a systematic review and meta-analysis.” Journal of affective disorders 278 (2021): 542-555.
Krystal, John H., et al. “[Infusions]: a paradigm shift for depression research and treatment.” Neuron 101.5 (2019): 774-778.
2017 consensus from the American Psychiatric Association.
Sanacora, Gerard, et al. “A consensus statement on the use of [infusions] in the treatment of mood disorders.” JAMA psychiatry 74.4 (2017): 399-405.
Infusions, Anxiety, PTSD & OCD
Feder, Adriana, et al. “A randomized controlled trial of repeated [infusions] administration for chronic posttraumatic stress disorder.” American Journal of Psychiatry 178.2 (2021): 193-202.
2021 review of [Infusions] for PTSD and putative mechanisms.
Asim, Muhammad, et al. “[Infusions] For Post-Traumatic Stress Disorders And It’s Possible Therapeutic Mechanism.” Neurochemistry International (2021): 105044.
2021 review for addiction, OCD and eating disorders.
Martinotti, Giovanni, et al. “Therapeutic Potentials of [Infusions] in Obsessive–Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature.” Brain Sciences 11.7 (2021): 856.
2020 review for the treatment of anxiety disorders.
Banov, Michael D., et al. “Efficacy and safety of [infusions] in the management of anxiety and anxiety spectrum disorders: a review of the literature.” CNS spectrums 25.3 (2020): 331-342.
2020 review of [Infusions] for PTSD
Feder, Adriana, et al. “The emergence of [infusions] as a novel treatment for posttraumatic stress disorder.” Advances in Pharmacology 89 (2020): 261-286.
2020 review for the treatment of OCD.
Sharma, Lavanya P., et al. “Clinical utility of repeated intravenous [infusions] treatment for resistant obsessive-compulsive disorder.” Asian journal of psychiatry 52 (2020): 102183.
Infusions & Substance Use
2022 systematic review of 83 trials.
Walsh, Zach, et al. “[Infusions] for the treatment of mental health and substance use disorders: comprehensive systematic review.” BJPsych Open 8.1 (2022).
2021 review for alcohol use disorder.
Worrell, Stephen D., and Thomas J. Gould. “Therapeutic Potential of [Infusions] for Alcohol Use Disorder.” Neuroscience & Biobehavioral Reviews (2021).
2021 review for addiction, OCD and eating disorders.
Martinotti, Giovanni, et al. “Therapeutic Potentials of [Infusions] in Obsessive–Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature.” Brain Sciences 11.7 (2021): 856.
2021 [Infusions] for cannabis use disorder.
Azhari, Nour, et al. “[Infusions]-facilitated behavioral treatment for cannabis use disorder: a proof of concept study.” The American journal of drug and alcohol abuse 47.1 (2021): 92-97.
2019 RCT for cocaine dependence.
Dakwar, Elias, et al. “A single infusion combined with mindfulness-based behavioral modification to treat cocaine dependence: a randomized clinical trial.” American Journal of Psychiatry 176.11 (2019): 923-930.
2019 RCT for cocaine use disorder.
Dakwar, E., et al. “Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist [Infusions]: a randomized, crossover trial.” Molecular psychiatry 22.1 (2017): 76-81.
2018 systematic review of [Infusions] for substance use disorders.
Jones, Jennifer L., et al. “Efficacy of [infusions] in the treatment of substance use disorders: a systematic review.” Frontiers in psychiatry 9 (2018): 277.